Intermedia is about the existence of combinatorial possibilities and hybridity leading to heterogeneity and complexity. The volume embraces this plurality and explores multiple historical origins and possible futures. Theories of “high” and “low” culture are examined and debated. A proposal on intermedia as liminal interface design space in new media is developed and presented. A variety of cases that expand and reshape the discussion on the operative workings of intermedia in diverse media forms and artistic genres including comic art, costume design, film, music, mythical narrative, new media, painting, poetry, television, textile art and game design are elaborated and discussed.